IP Archives of Cytology and Histopathology Research
Official Publication of Khyati Education and Research Foundation
Official Publication of Khyati Education and Research Foundation
Print ISSN: 2581-5725
Online ISSN: 2456-9267
CODEN : IACHCL
IP Archives of Cytology and Histopathology Research (ACHR) open access, peer-reviewed quarterly journal publishing since 2016 and is published under the Khyati Education and Research Foundation (KERF), is registered as a non-profit society (under the society registration act, 1860), Government of India with the vision of various accredited vocational courses in healthcare, education, paramedical, yoga, publication, teaching and research activity, with the aim of faster and better dissemination of knowledge, we will be publishing the article more...Leptomeningeal malignant melanoma is a rare disease associated with poor prognosis in which tumor spreads to meninges surrounding brain and spinal cord. Here, we discuss a case of a 47 year male who presented with complain of forgetfulness, difficulty in walking, urinary incontinence, drowsiness, unable to speak, seizure. A CT brain showed hyperdense area and significant perilesional oedema in right temporo-parietal region. It causes mass effect. Subdural haemorrhage noted in right parietal region with periventricular hypo density. For that patient operated for right side VP shunt and right fronto-temporoparietal craniotomy with excision of right temporal space occupying lesion. HPE showed tumour to be composed of neoplastic cells arranged in sheets nest and peritheliomatous pattern. Cells are epithelioid to spindly in nature. Mitosis are ( >20/10 HPF ). Cytoplasm of neoplastic cells showed melanin pigment.
Primary central nervous system, malignant melanoma, leptomeningeal melanomatosis.