- Visibility 448 Views
- Downloads 456 Downloads
- Permissions
- DOI 10.18231/j.achr.2025.017
-
CrossMark
- Citation
Synchronous cutaneous malignancies in a patient with vitiligo: A rare case report
- Author Details:
-
Nandita Katoch *
-
Nikhil Verma
Background: Synchronous malignancies of skin are quite rare and association of these synchronous malignancies with vitiligo have never been reported. Here we present a case with synchronous presence of basal cell carcinoma, squamous cell carcinoma and basosquamous carcinoma at different anatomical locations in a patient with vitiligo.
Case Report: A 78-year-old male presented to Dermatology OPD with history of raised lesions over nose, lip, and chest for 1 month. Patient was a known case of vitiligo but was not on any medication or PUVA therapy. Punch biopsy was taken from these lesions and sent to Department of Pathology for histopathological examination. Microscopic examination from the sections from nose biopsy revealed histopathological features consistent with Basal Cell Carcinoma. Sections from lip biopsy revealed histopathological features consistent with Squamous Cell Carcinoma. Sections from chest lesion revealed histopathological features of a poorly differentiated carcinoma, basosquamous carcinoma was kept as first possibility.
Conclusion: Our patient, an elderly male with Vitiligo, without history of PUVA, developed synchronous non-melanotic malignancies. Genetic and epigenetic factors might have led to this carcinogenesis. Our case contributes to the awareness of development of synchronous non melanotic malignancies in vitiligo patient.
Keywords: Synchronous malignancies, Vitiligo, Squamous cell carcinoma, Basal cell carcinoma, Basosquamous carcinoma.
References
- Warren S, Gates O. Multiple primary malignant tumors, a survey of the literature and statistical study. Am J Cancer. 1932;16:1358–414.
- Zhai C, Cai Y, Lou F, Liu Z, Xie J, Zhou X, et al. Multiple primary malignant tumors – a clinical analysis of 15,321 patients with malignancies at a single center in China. J Cancer. 2018;9(16):2795–801.
- Weng C, Ho HJ, Chang YL, Chang YT, Wu CY, Chen YJ, et al. Reduced risk of skin cancer and internal malignancies in vitiligo patients: a retrospective population-based cohort study in Taiwan. Sci Rep. 2021;11(1):20195.
- Ban L, Labbouz S, Grindlay D, Batchelor JM, Ratib S. Risk of skin cancer in people with vitiligo: A systematic review and meta- analysis. Br J Dermatol. 2018;179(4):971–2.
- Kim HS, Kim HJ, Hong ES, Kim KB, Lee JD, Kang TU, et al. The incidence and survival of melanoma and nonmelanoma skin cancer in patients with vitiligo: a nationwide population‐based matched cohort study in Korea. Br J Dermatol. 2020;182(4):907–15.
- McDaniel B, Badri T, Steele RB. Basal Cell Carcinoma. [Updated 2022 Sep 19]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023. Available from: https://www.ncbi.nlm.nih.gov/books/NBK482439/
- Fania L, Didona D, Di Pietro FR, Verkhovskaia S, Morese R, Paolino G, et al. Cutaneous squamous cell carcinoma: from pathophysiology to novel therapeutic approaches. Biomedicines. 2021;9(2):171.
- Calanchini-Postizzi E, Frenk E. Long-term actinic damage in sun- exposed vitiligo and normally pigmented skin. Dermatologica. 1987;174(6):266–71.
- Chiang A, Tan CZ, Kuonen F, et al. Genetic mutations underlying phenotypic plasticity in basosquamous carcinoma. J Investig Dermatol. 2019;139(11):2263–71.
- Murgia G, Denaro N, Boggio F, Hodgkinson LM, Chiang F, Cho RJ, et al. Basosquamous carcinoma: comprehensive clinical and histopathological aspects, novel imaging tools, and therapeutic approaches. Cells. 2023;12(23):2737.
- Seo SL, Kim IH. Squamous cell carcinoma in a patient with generalized vitiligo. J Am Acad Dermatol. 2001;45(6 Suppl S):227–
- Buckley DA, Rogers S. Multiple keratoses and squamous carcinoma after PUVA treatment of vitiligo. Clin Exp Dermatol. 1996;21(1):43–5.
- Takeda H, Mitsuhashi Y, Kondo S. Multiple squamous cell carcinoma in situ in vitiligo lesions after long-term PUVA therapy. J Am Acad Dermatol. 1998;38(2 Pt 1):268–70.
- Vijay A, Jain SK, Kumar R. Squamous cell carcinoma on vitiligo patch: A rare association. Pigment Int. 2017;4(2):115.
- Dhawan AK, Verma P, Singal A, Sharma S. Squamous cell carcinoma complicating vitiligo in an Indian man. J Cutan Aesthet Surg. 2012;5(1):36–7.
- Fiszon-Cerqueira L, Ramos-E-Silva M, Guerreiro FB, Cistaro- Serrano M, Carneiro AHC, Gomes MK. Giant basal cell carcinoma associated with vitiligo. Clin Case Rep. 2019;7(9):1782–6.
- Pineider J, Ken KM, Savory S, Nijhawan RI. Basal cell carcinoma masquerading as vitiligo in a young woman. JAAD Case Rep. 2020;6(7):584–6.
- Rustemeyer J, Günther L, Deichert L. A rare association: basal cell carcinoma in a vitiliginous macula. Oral Maxillofac Surg. 2011;15(3):175–7.
- Zhang XT, Ma XH, Jin WW, Chen SS, Xu HT. Concurrence of multiple cutaneous malignancies on sun-exposed vitiligo skin of a patient: A case report and review of the literature. Indian J Dermatol. 2018;63(4):346–8.
How to Cite This Article
Vancouver
Katoch N, Verma N. Synchronous cutaneous malignancies in a patient with vitiligo: A rare case report [Internet]. IP Arch Cytol Histopathol Res. 2025 [cited 2025 Oct 02];10(2):62-64. Available from: https://doi.org/10.18231/j.achr.2025.017
APA
Katoch, N., Verma, N. (2025). Synchronous cutaneous malignancies in a patient with vitiligo: A rare case report. IP Arch Cytol Histopathol Res, 10(2), 62-64. https://doi.org/10.18231/j.achr.2025.017
MLA
Katoch, Nandita, Verma, Nikhil. "Synchronous cutaneous malignancies in a patient with vitiligo: A rare case report." IP Arch Cytol Histopathol Res, vol. 10, no. 2, 2025, pp. 62-64. https://doi.org/10.18231/j.achr.2025.017
Chicago
Katoch, N., Verma, N.. "Synchronous cutaneous malignancies in a patient with vitiligo: A rare case report." IP Arch Cytol Histopathol Res 10, no. 2 (2025): 62-64. https://doi.org/10.18231/j.achr.2025.017