Background: Synchronous malignancies of skin are quite rare and association of these synchronous malignancies with vitiligo have never been reported. Here we present a case with synchronous presence of basal cell carcinoma, squamous cell carcinoma and basosquamous carcinoma at different anatomical locations in a patient with vitiligo.
Case Report: A 78-year-old male presented to Dermatology OPD with history of raised lesions over nose, lip, and chest for 1 month. Patient was a known case of vitiligo but was not on any medication or PUVA therapy. Punch biopsy was taken from these lesions and sent to Department of Pathology for histopathological examination. Microscopic examination from the sections from nose biopsy revealed histopathological features consistent with Basal Cell Carcinoma. Sections from lip biopsy revealed histopathological features consistent with Squamous Cell Carcinoma. Sections from chest lesion revealed histopathological features of a poorly differentiated carcinoma, basosquamous carcinoma was kept as first possibility.
Conclusion: Our patient, an elderly male with Vitiligo, without history of PUVA, developed synchronous non-melanotic malignancies. Genetic and epigenetic factors might have led to this carcinogenesis. Our case contributes to the awareness of development of synchronous non melanotic malignancies in vitiligo patient.
Keywords: Synchronous malignancies, Vitiligo, Squamous cell carcinoma, Basal cell carcinoma, Basosquamous carcinoma.
