A rare case of primary choriocarcinoma of lung metastasizing to brain

• Author Details:   
• Lakshmi Agarwal ^*
• Kalpit Jain
• Manmohan Agrawal
• Nidhi Agarwal

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Primary choriocarcinoma of the lung (PCC) is a rare and aggressive malignancy with a poor prognosis. A 24-year-old female presented with headaches and seizures. Brain MRI revealed a metastatic lesion, and biopsy showed trophoblastic tumor cells. Elevated Beta-HCG levels suggested gestational trophoblastic disease, but imaging ruled out uterine involvement. Chest CT revealed a lung mass, and biopsy confirmed PCC. The diagnosis was established based on the absence of a uterine primary and lung involvement. Despite surgery and chemotherapy, prognosis remains poor. This case highlights the importance of considering PCC in patients with metastatic disease and high Beta-HCG levels, emphasizing the need for thorough evaluation for accurate diagnosis and timely treatment.

Keywords: Choriocarcinoma, Lung, Human β-hCG, Brain