- Received July 27, 2022
- Accepted July 21, 2022
- Publication November 30, 2022
- Visibility 3 Views
- Downloads 0 Downloads
- DOI 10.18231/j.achr.2022.059
-
CrossMark
- Citation
Multilocular cystic renal cell carcinoma of low malignant potential- A rare case report
- Author Details:
-
Vidya Bhat *
Vidya Bhat *
Introduction
Multilocular cystic renal cell carcinoma (MCRCC), also known as multilocular clear cell renal cell carcinoma (RCC), is a rare cystic tumor of the kidney with an excellent outcome. It occurs in about 3.1-6% of the conventional RCC.[1], [2], [3] It is usually included in the group of tumors of undetermined malignant potential with low nuclear grade. Adult patients are eight times more likely to be female and most often present with flank mass, abdominal pain, or hematuria.[3], [4]
Case Details
A 49 year old male patient presented to the department of urology with complaints of left sided abdominal distension since 2years.Investigations- Urinalysis didn’t reveal any obvious abnormalities, urine cytology revealed an inflammatory process. Laparoscopic left radical nephrectomy was done and specimen was sent to the department of pathology. We received a specimen of left nephrectomy in formalin, with perirenal fat totally measuring 15x9.5x5 cm. The lower pole of the kidney appeared bosselated and on cut section revealed a multiloculated cystic neoplasm measuring 6x5 cm ([Figure 1]). The tumor appeared multiseptate, vareigated and well encapsulated with a non- communicating cysts ranging in size from 0.1 to 0.7 cm. The cysts were filled with straw coloured fluid. No other solid nodules or papillary projections seen.
Microscopy
Sections revealed a multicystic tumor seperated by thick fibrous septae. These septae were lined by cells which were cuboidal to low columnar with clear cytoplasm ([Figure 2]a). These clear cells had a small hyperchromatic nucleus with minimal anisonucleosis and inconspicuous nucleoli with Furhman nuclear grade of 1 or 2.There was no mitosis seen ([Figure 2]b).There was no tumor invasion into adjacent renal parenchyma, and the tumour cells were limited to the kidney capsule, and no extension to the major vessels as well as perinephric fat. There was no associated tumor necrosis/infiltration into the ureter. No sarcamatoid/rhabdoid features were seen.Based on these findings, a diagnosis of multilocular cystic clear cell renal neoplasm of low malignant potential was given with following staging pT1NxMx.
Discussion
Multilocular cystic renal cell carcinoma of low malignant potential (MCRCC) has a very low incidence of < 2% and first reported by Perlmann in 1928 and named it as lymphangiohemangioma. [1]
Tumor has a low incidence accounts for about 1- 2% of all renal neoplasms [1] and about 3.1 to 6% of clear cell RCC as per a study done by Chowdhary et al.[1], [2] They have been found patients with a mean age of 51 years and affects individuals of the age group 20 to 76.[1], [2] The males are more commonly affected than females with a male to female ratio of 3:1. [3]
The 2004 WHO classification recognizes MCRCC as a rare variant of clear cell RCC with a good prognosis.[shivakumaraswamy et al]. Some of the differential diagnoses that were considered consisted of other cystic lesions of kidney, including tubulocystic carcinoma, primary cystic nephroma, extensively cystic clear cell RCC, and clear cell papillary RCC. Tubulocystic carcinoma differs from MCRCC in that the cystic spaces are lined by flat cuboidal and sometimes hobnail-type cells with eosinophilic cytoplasm and variable nuclear atypia, usually with nucleolar prominence in the range of Fuhrman Grade 2 or 3, which is incompatible with MCRCC. In addition, the septal lining of tubulocystic carcinoma do not harbor clusters of clear cells.[3] Cystic nephroma may have few clear cells lining the septae, they are more focal and donot have a diffuse arrangement. In clear cell papillary neoplasm, papillary fronds are prominent, whereas in MCRCC do not show papillary pattern. In 2016, the WHO published a new classification on renal tumors, and as per the evidence and data collected they had termed this tumor as MCRN-LMP
Multilocular cystic clear cell renal neoplasm of low malignant potential is a tumors having good prognosis. As seen in a study by Li et al, which studied 76 patients, there was no recurrence of tumors in the patients on follow up. [5] In a study done by Murad et al, it was concluded that the tumor was a low grade variant of RCC. [4] In a large series done by Suzigan et al it was found that 82% of their cases were in the T1 stage with a low nuclear grade in 62% cases and a 100% 5 year survival rate. [1], [2], [6]
Even though majority of case reports have reported a low malignant potential of this tumour, in 2010 Walsh et al reported the first case of this tumour metastasizing to one out of 7 intra aortocaval lymph nodes. [7], [8]
Conclusions
Multilocular cystic clear cell renal neoplasm of low malignant potential is now recognised as a seperate entity as per the WHO classification of 2016. This tumour has shown an indolent behaviour in the previous cases. We report this case as, identification and diagnosis of this rare tumor helps the patient as it has a good prognosis.
Source of Funding
None.
Conflicts of Interest
There is no conflict of interest.
References
- AR Chowdhury, D Chakraborty, P Bhattacharya, RK Dey. Multilocular cystic renal cell carcinoma a diagnostic dilemma: A case report in a 30-year-old woman. Urol Ann 2013. [Google Scholar]
- JN Eble, SM Bonsib. Extensively cystic renal neoplasms: cystic nephroma, cystic partially differentiated nephroblastoma, multilocular cystic renal cell carcinoma, and cystic hamartoma of renal pelvis. Semin Diagn Pathol 1998. [Google Scholar]
- S Udasimath, J Niranjan, R Puruhotham, KR Nagesha. Multilocular cystic renal cell carcinoma in a 23 year old female. Urol Ann 2016. [Google Scholar] [Crossref]
- T Murad, W Komaiko, R Oyasu, K Bauer. Multilocular cystic renal cell carcinoma. Am J Clin Pathol 1991. [Google Scholar] [Crossref]
- T Li, J Chen, Y Jiang, X Ning, S Peng, J Wang. Multilocular Cystic Renal Cell Neoplasm of Low Malignant Potential: A Series of 76 Cases. Clin Genitourin Cancer 2016. [Google Scholar] [Crossref]
- S Suzigan, A Lopez-Beltran, R Montironi, R Drut, A Romero, T Hayashi. Multilocular cystic renal cell carcinoma: a report of 45 cases of a kidney tumor of low malignant potential. Am J Clin Pathol 2006. [Google Scholar] [Crossref]
- T J Walsh, P Naik, P Sweeney, J Fitzgibbon, M Murphy. Metastatic multilocular cystic renal cell carcinoma - Malignant cells clearly a treatment dilemma. J Lab Physicians 2014. [Google Scholar]
- SP Wahal, K Mardi. Multilocular cystic renal cell carcinoma: a rare entity with review of literature. J Lab Physicians 2014. [Google Scholar]