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Histopathological spectrum of gall Bladder diseases in cholecystectomy specimens at a Rural tertiary hospital of Purvanchal in North India-Does it differ from South India?

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Original Article

Author Details : Vaishali Dhananjay Kotasthane, Dhananjay Shrikant Kotasthane*

Volume : 5, Issue : 1, Year : 2020

Article Page : 91-95

https://doi.org/10.18231/j.achr.2020.018

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Abstract

Introduction: Gall Bladder (GB) diseases are one of the most common digestive system diseases, the
prevalence of which is variable within India and ranges from 2-29%. Cholelithiasis (gallstones) is the
commonest lesion and accounts for more than 95% of GB diseases. Gall bladder carcinoma showed
regional differences in India with prevalence ranging from 0.52% in southern India and as high as 9.6% in
northern India.
Aims and Objectives: 1)To identify the morphological spectrum of diseases affecting the gall bladder.
2)To identify the most common histopathological lesion and its correlation with clinical and demographic
data of the patient. 3)T o identify the frequency of Gall Bladder Carcinoma (GBC) and its correlation with
clinical and demographic data of the patient and pre-existing lesions if any.
Materials and Methods: This study was non-participatory descriptive study carried out retrospectively
for a period of one year in the Dept. of Pathology, HIMS,from August 2018 to July 2019. All the specimens
received in the study period were included in the study. The gross and microscopic findings on H & E slide
were included in the study. The descriptive statistics w as applied to analysed data.
Results: Total 86 cholecystectomy specimens were received in the Department of Pathology during
one year study period. Non-neoplastic lesions (97.67%) of gall bladder outnumbered the neoplastic
lesions (2.33%). Most common histopathological lesion was chronic cholecystitis (95.34%). Varied
histopathological spectrum was seen comprising of chronic calculous cholecystitis (73.26%), chronic
acalculous cholecystitis (13.95), chronic cholecystitis with cholesterosis (13.95%), Xanthogranulomatous
cholecystitis (2.33)%), Acute calculous cholecystitis (1.16%), acute gangrenous GB (1.16%), GBC
(2.33%). In non-neoplastic lesions, female predilection (70.24%) was seen over male (29.76%) accounting
for F:M ratio of 2.4:1, two cases of GBC exclusively seen in females associated with gall stones. Nonneoplastic
lesions were common between the age group of 26-50 years accounting for 67.45% where as
neoplastic lesions were common in the age group of >60years.
Conclusion: Chronic cholecystitis with pigmented gall stone was the commonest GB disease in the present
study. The study also revealed that females have increased preponderance for the development of all the
gall bladder diseases including malignancy. Non-neoplastic lesions were more common till 5th decade in
the present study whereas females in the 5th and 6th decade of life were prone for malignancy of gall
bladder which was associated with gall stones.

Keywords: Gall bladder, Cholecystectomy, Histopathology.

How to cite : Kotasthane V D, Kotasthane D S, Histopathological spectrum of gall Bladder diseases in cholecystectomy specimens at a Rural tertiary hospital of Purvanchal in North India-Does it differ from South India?. IP Arch Cytol Histopathol Res 2020;5(1):91-95

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