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Lymph node tissue thyroglobulin washout measurement in metastatic papillary thyroid carcinoma

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Original Article

Author Details : Luis E. Barrera-Herrera, Viviana Barrera-Penagos, Mauricio A Palau-Lázaro, Humberto Rivera-Gonzalez, Paula A Rodriguez-Urrego A Rodriguez-Urrego*

Volume : 5, Issue : 4, Year : 2020

Article Page : 295-301

https://doi.org/10.18231/j.achr.2020.064

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Abstract

Aims and Background: Papillary thyroid carcinoma is the most frequent subtype of thyroid carcinoma and usually has a favorable prognosis, however, locoregional metastases are reported in approximately 5-20% of the cases. Literature reports that when using a combination of ultrasound, fine needle aspiration and tissue thyroglobulin levels to diagnose metastases, sensitivity and specificity radically increase. The aim of this study was to validate tissue thyroglobulin measurement in local patients and compare these results to radiological and histopathological diagnosis.
Materials and Methods: A cross-sectional study was carried out to measure tissue thyroglobulin levels in lymph nodes obtained by fine needle aspiration and/or biopsy from patients with adenopathy suspected of metastatic papillary thyroid carcinoma. Tissue thyroglobulin was measured by chemiluminescence and was considered positive for metastatic papillary thyroid carcinoma when levels were ?1.7 ng / mL in patients with a history of thyroidectomy and > 36 ng/mL in patients without a history of thyroidectomy (4).
Results: Our results confirm that the measurement of TTG by chemiluminescence can be made from the same tissue sample, giving the patient and the clinician greater diagnostic certainty.
Conclusions: TTG measurement through chemiluminescence is a low-cost technique that can improve diagnostic performance of pathological analysis. Levels can be measured from the same needle used in cytology/biopsy providing both the patient and clinician greater diagnostic certainty, increasing the diagnostic sensitivity and specificity of the procedure without the need for further invasive interventions.
Key Message: TTG measurement through chemiluminescence is a low-cost technique that can improve diagnostic performance of pathological analysis.

Keywords: Papillary thyroid carcinoma thyroglobulin local lymph node assay, Neoplasm metastasis.

How to cite : Barrera-herrera L E, Barrera-penagos V, Palau-lázaro M A, Rivera-gonzalez H, Rodriguez-urrego P A R A, Lymph node tissue thyroglobulin washout measurement in metastatic papillary thyroid carcinoma. IP Arch Cytol Histopathol Res 2020;5(4):295-301

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