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A study on diagnostic and prognostic significance of laboratory parameters and its correlation with HRCT of lung in Covid-19 patients

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Original Article

Author Details : Radha Mohan Meena, Rajeev Saxena, Lakshmi Agarwal*, Nidhi Agarwal, Sakshi Singh

Volume : 8, Issue : 1, Year : 2023

Article Page : 23-28

https://doi.org/10.18231/j.achr.2023.006

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Abstract

Introduction: Coronaviruses had a wide range of symptoms from asymptomatic to severe illness and has caused significant morbidity and death among large population infected with this virus.
Aims and Objectives: To correlate CT severity score with each blood parameter like (TLC counts, Absolute neutrophil count, Absolute lymphocyte count, neutrophilic/lymphocytic ratio, quantitative D-dimer, ferritin, CRP, IL-6 and LDH). To assess diagnostic and prognostic significance of each parameter in predicting severity of disease.
Materials and Methods: The present study was a 1-year prospective, a hospital-based study from 1 August 2020 to 31 July 2021 and included 100, COVID-19 confirmed cases. The clinical, radiological and laboratory reports were collected. The CT score were compared with different blood parameters. The results were analyzed statistically using correlation coefficient(r).
Results and Observations: 27 patients having a CT severity score 1-10 were graded in mild category. 27 patients having CT severity score 11-15 were graded in moderate category.34 patients having CT severity score 16- 20 were graded as severe.12 patients having CT severity score 21-25 were graded as very severe. The present study showed raised TLC count > 11000 / µl in 35% patients suffering from COVID -19. Absolute neutrophil count > 7000/µl was seen in 50 % patients. 65% patients showed Absolute lymphocyte count <1000> 3.5 was seen in 83% patients. Raised D-Dimer >500 ng/ml was observed in 74 % patients. 92 % subjects showed raised Serum ferritin >150ng/ml. IL-6 >10pg/ml was seen in 92 % patients. Q-CRP >10 mg/l was seen in 97 % patients.
Conclusion: HRCT chest severity score of patients with COVID-19 has positive correlation with various laboratory parameters and hence can be used as an indicator of disease severity. It can play a vital role in the management of COVID-19 and should be used for comprehensive evaluation.
 

Keywords: COVID­19, SARS­Cov­2, ACE­2, ANC, N/L ratio, LDH

How to cite : Meena R M, Saxena R, Agarwal L, Agarwal N, Singh S, A study on diagnostic and prognostic significance of laboratory parameters and its correlation with HRCT of lung in Covid-19 patients. IP Arch Cytol Histopathol Res 2023;8(1):23-28

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