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Clear cell adenocarcinoma of posterior urethra- A rare histological subtype of female genitourinary cancer

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Case Report

Author Details : Prachi*, Hema Malini Aiyer

Volume : 8, Issue : 1, Year : 2023

Article Page : 53-55

https://doi.org/10.18231/j.achr.2023.012

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Abstract

Urethral Clear cell adenocarcinoma is a very rare variant of lower urinary tract malignancy. We present a 62-year old lady who complained of hematuria, obstructive urinary symptoms and pain abdomen. Her MRI pelvis revealed a mass in the posterior urethra measuring 30x20x15mm. Further she underwent total urethrectomy with regional lymph node dissection. Histology demonstrated features consistent with clear cell adenocarcinoma with 8/29 positive lymph nodes. Immunohistochemically cells were positive for CK7(+4), CD10(+4), HMWCK(+2) and PAX-8(+3). Whilst it was non- immunoreactive for GATA3, CK20, uroplakin and p-63. Subsequent PET scans have demonstrated lymphatic disease progression, and later on, the patient succumbed to disease after one year of diagnosis.
 

Keywords: Uretheral clear cell adenocarcinoma, Urethrectomy, Immunohistochemistry, Histology

How to cite : Prachi, Aiyer H M, Clear cell adenocarcinoma of posterior urethra- A rare histological subtype of female genitourinary cancer. IP Arch Cytol Histopathol Res 2023;8(1):53-55

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