IP Archives of Cytology and Histopathology Research

Print ISSN: 2581-5725

Online ISSN: 2456-9267

CODEN : IACHCL

IP Archives of Cytology and Histopathology Research (ACHR) open access, peer-reviewed quarterly journal publishing since 2016 and is published under the Khyati Education and Research Foundation (KERF), is registered as a non-profit society (under the society registration act, 1860), Government of India with the vision of various accredited vocational courses in healthcare, education, paramedical, yoga, publication, teaching and research activity, with the aim of faster and better dissemination of knowledge, we will be publishing the article more...

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Review Article


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83-89


Authors Details

Barani Karikalan*, Srikumar Chakravarthi


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Genes involved in chronic wound healing and their therapeutic potential


Review Article

Author Details : Barani Karikalan*, Srikumar Chakravarthi

Volume : 8, Issue : 2, Year : 2023

Article Page : 83-89

https://doi.org/10.18231/j.achr.2023.020



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Abstract

Chronic wounds are wounds that fail to progress through the normal stages of healing and remain open for an extended period of time. These wounds often require specialized treatment approaches. While the genes involved in wound healing play important roles in chronic wound treatment as well, the specific genetic factors contributing to chronic wounds are still being studied. Some of the genes and genetic factors that have been implicated in chronic wound healing and their potential for treatment include Transforming Growth Factor-Beta (TGF-β) Family, Matrix Metalloproteinases (MMPs), Transforming Growth Factor-Alpha (TGF-?), Hypoxia-Inducible Factor-1 (HIF-1), Vascular Endothelial Growth Factor (VEGF), Nitric Oxide Synthase (NOS) and Wound-Healing-Associated microRNAs. It's important to note that chronic wounds are multifactorial, and their treatment requires a comprehensive approach addressing various factors beyond genetic factors alone. Other aspects such as underlying medical conditions, infection, local wound environment, and patient-specific factors also play crucial roles in chronic wound management.
 

Keywords: Matrix Metalloproteinases, Transforming Growth Factor-Alpha, Nitric Oxide Synthase


How to cite : Karikalan B, Chakravarthi S, Genes involved in chronic wound healing and their therapeutic potential. IP Arch Cytol Histopathol Res 2023;8(2):83-89

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