---

Assessment of immunohistochemical expression of claudin-1 in oral squamous cell carcinoma and its clinicopathological correlation

---

Review Article

Author Details : Poonam Rajendra Zanwar*, Jayanti Govind Humbe, Jyoti Dilip Bhavthankar, Mandakini Subhash Mandale, Priyanka Sanjay Pachpande

Volume : 8, Issue : 3, Year : 2023

Article Page : 161-168

https://doi.org/10.18231/j.achr.2023.038

Suggest article by email

Get Permission

---

Abstract

Oral carcinogenesis is complex and multi-step process, which results from various deleterious habits, multiple environmental factors and genetic susceptibility. CLDN-1 expression is regulated oncogenic Wnt/B-catenin transduction pathway. They recruit matrix metalloproteinases (MMPs) on the cell surface to achieve elevated focal concentrations and eventual activations of proMMP2. These collagenases are responsible for the breakdown of extracellular matrix proteins and thus facilitate invasion and spread of malignant cells. Reduced cell-cell adhesion is associated with loss of contact inhibition of proliferation. This allows escape from growth control signals and triggers carcinogenesis. Significant correlation was observed between histopathological grade of the tumor with the localization and immunostaining intensity of CLDN-1. Determination of localization of CLDN-1 for a particular patient may be important to decide site (cytoplasmic or nuclear) for targeting CLDN-1. This targeted drug therapy for CLDN-1 may prevent worsening of the disease in the patient, resulting in better prognosis.
 

Keywords: Oral squamous cell carcinoma, Claudin 1, prognosis

How to cite : Zanwar P R, Humbe J G, Bhavthankar J D, Mandale M S, Pachpande P S, Assessment of immunohistochemical expression of claudin-1 in oral squamous cell carcinoma and its clinicopathological correlation. IP Arch Cytol Histopathol Res 2023;8(3):161-168

This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.