IP Archives of Cytology and Histopathology Research

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Get Permission Selvi, Revathishree, Chandana, Khan, and Abilash: Study of Appropriateness of FFP transfusions in a tertiary care centre


Introduction

Blood transfusion is an essential part of modern health care.1 Indiscriminate use of blood components is on the rise due to easy availability of sophisticated blood banking services. Auditing of blood transfusion practice is therefore necessary to ensure the rationale use of blood components. First audit of transfusion practices was done by Bock as early as 1936. Several studies on blood audit have been conducted since then, evaluating the appropriateness of blood transfusions and have helped in introducing structured guidelines for use of blood products relevant to their situations.2

The most important feature to assess rational use is a note by the physician in progress sheet or other appropriate part of the patient record stating the indications for transfusion. Appropriate documentation is beneficial in assessing transfusion justification within established clinical guidelines.3

Evaluation of appropriate use of blood and its components forms a component of quality assurance and the main objective is the improvement of patient care by reducing unnecessary transfusions which incidentally share the hazards of iatrogenic diseases. From an economic point of view, this evaluation can also improve resource management.2 The aim of this study was to evaluate appropriate usage of Fresh frozen plasma (FFP).

Materials and Methods

This study was conducted in a tertiary care centre. A total of 4236 blood request forms were analyzed in this study out of which 8.2% (n=349) were for FFP. Number of units requested were noted and appropriateness of requested transfusions was assessed according to the National guidelines on transfusion.4

Each transfusion was classified as one of the following categories:

  1. Transfusion appropriate and number of units transfused appropriate

  2. Transfusion appropriate but number of units transfused inappropriate

  3. Transfusion considered inappropriate

  4. Quality of documentation did not allow an accurate decision regarding appropriateness.5

Request forms of neonates and children upto 18 years of age were excluded from the study. CT ratio was calculated with the formula: Cross-match (C) to Transfusion ratio = No. of units cross-matched / No. of units transfused. Microsoft Excel was used for data entry and analysis and results were expressed in percentages.

Results

A total of 4236 blood request forms were analyzed in this study, out of which 8.2% (n=349) were for FFP. Out of 349 requests for FFP, PTINR values were mentioned in 63% (n=220) and not mentioned in 37% (n=349). Out of these 349 FFP requests, 53.9% (n=188) requests were considered appropriate, 29.8% (n=104) were considered inappropriate and 16.3% (n=57) requests could not be assessed since PTINR values were not available. Out of the 29.8% inappropriate transfusions, in 13.8% (n=48) transfusion was appropriate but number of units transfused were inappropriate and in 16% (n=56) transfusion was considered inappropriate. 2351 units of FFP were ordered and 2283 units were issued and CT ratio was 1.

Discussion

Blood has no substitute and blood transfusion is life saving in many situations.6 However indiscriminate use of blood components is on the rise due to easy availability of sophisticated blood banking services. Many studies suggest that monitoring of blood transfusion practice and its healthy criticism have brought a positive response among clinicians and thus decrease in the number of inappropriate transfusions.7 Dylag et al showed that out of the total 2746 blood component transfusions, 13.5% (n=371) were of whole blood, 75.5% (n=2073) of PRBCs, 10.2% (n=281) were of FFPs and 0.8% (n=21) were of platelet concentrates.8 In this present study there were total of 4236 requests, out of which 76.6% (n=3246) requests were for PRBC, 8.3% (n=352) were for Platelets, 8.2% (n=349) were for FFP and 6.8% (n=289) were for more than 1 components. Whole blood was the most ordered component earlier whereas now it has become obsolete and appropriate components are used. Usage of appropriate components instead of whole blood has 2 advantages. It reduces the increased volume load dumped into the patient unnecessarily and help in reducing unnecessary utilization of blood components which is a valuable resource.

In a study conducted by Friedman et al, he found that out of 172 transfusions, 51% (n=88) were adequately documented, 23.2% (n=40) were partly documented and 25.4% (n=44) were inadequately documented. It was also noted that inappropriate transfusions were associated with inadequately documented forms. Only 9% (n=8) of adequately documented forms were not justifiable whereas 50% (n=20) of partly documented and 73% (n=32) of inadequately documented were found to be inappropriate.3 In the present study, PTINR values were not mentioned in 37% (n=349). Recording indications for transfusion on the request form could make appropriateness evaluation easier and could act as a reminder for clinicians.9 Diagnosis and indications were collected from various wards through phone in many cases and could not be traced in 16.3% (n=57) forms even after these efforts. Investigation details that are not mentioned (37%) were collected from Hospital Information System (electronic data).

30.4% of inappropriate FFP transfusions were noted in a study by Viswanathan et al.10 23.1% of inappropriate FFP transfusions were recorded by kakkar et al.11 39% of FFP transfusions were considered inappropriate in a study conducted in the department of surgical oncology by Chatterjee et al.12 A study conducted by Basu et al found that 42% of FFP transfusions were inappropriate.13 32% of inappropriate FFP transfusions were also seen in a study conducted by Eagleton et al.14 Inappropriate transfusion as high as 73% was noted in a study conducted by Chng et al.15 Hui et al conducted a study on FFP transfusions which revealed that 28% of FFP transfusions were inappropriate.16 In a study conducted by Luk et al, it was stated that 53% of inappropriate transfusions were noted.17 In the present study, there were 349 FFP requests out of which 53.9% (n=188) requests were considered appropriate, 29.8% (n=104) were considered inappropriate and 16.3% (n=57) requests could not be assessed since PTINR values were not available. Appropriateness of FFP transfusions highly varies from study to study and in a large number of cases (16.3%) assessment could not be made which was a drawback due to inadequate investigation details.

Cross-match (C) to Transfusion ratio = No. of units cross-matched / No. of units transfused. A C/T ratio of <=2.5 is indicative of significant blood usage. A C/T ratio of >2.5 means that less than 40% of cross-matches are transfused.18 In another study conducted by Chawla et al, C/T ratio was around 2.5.19 In a study conducted by Abayomi et al, CT ratio was 2.1:1.20 In the present study, CT ratio was 1.0 for FFP. This indicates that there was significant blood usage in this hospital. The blood bank in this hospital has conducted CMEs and made few departmental meetings to explain significance of blood usage and this may be one of the reasons for good CT ratio in this hospital.

Conclusion

It was observed in this study that out of these 349 FFP requests, 53.9% (n=188) requests were considered appropriate, in 13.8% (n=48) transfusion was appropriate but number of units transfused were inappropriate and in 16% (n=56) transfusion was considered inappropriate and 16.3% (n=57) requests could not be assessed since PTINR values were not available. This indicates that significant number of inappropriate transfusions were noted. This issue has to be addressed and inappropriate transfusions should be avoided. This can be achieved by regular CME programmes, clinico-pathological meet, educational visits to various departments and development of hospital transfusion guidelines which has to be agreed and followed by clinicians.

Conflicts of Interest

All contributing authors declare no conflicts of interest.

Source of Funding

None.

References

2 

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3 

MT Friedman A Ebrahim Adequacy of Physician Documentation of Red Blood Cell Transfusion and Correlation With Assessment of Transfusion AppropriatenessArch Pathol Lab Med20061304474910.5858/2006-130-474-aopdor

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R K Saran Transfusion Medicine Technical Manual2nd Edn.Mehta Offset Pvt Ltd2003193223

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PJ Joy SJ Bennet The appropriateness of blood transfusion following primary total hip replacementAnn R Coll Surg Engl2012943201310.1308/003588412x13171221501384

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T S Venkatachalapathy A Prospective Audit of Blood Transfusion Reactions in Tertiary Care Hospital for the Use of Blood and Blood ComponentsJ Blood Disord Transfus20123118

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S Dylag E J Kucharz The use of blood and its components in two gynecological-obstetrical wards of selected Silesian hospitals in years 1996-2002Pol Merkur Lekarski201177195201

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C Vishwanathan R Jain M Kamath Blood utilization review in a tertiary care hospitalIndian J Haematol Blood Transf1999172631

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N. Kakkar R. Kaur J. Dhanoa Improvement in fresh frozen plasma transfusion practice: results of an outcome auditTransfus Med2004143231510.1111/j.0958-7578.2004.00505.x

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M Chatterjee Z S Bharucha Retrospective audit of transfusion practice in surgical oncologyIndian J Haematol Blood Transf19981610712

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S Basu N Marwaha Fresh frozen plasma: Indications and patterns of usageIndian J Haematol Blood Transf200119512

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W J Chng M K Tan P Kuperan An audit of fresh frozen plasma usage in an acute general hospital in SingaporeSingapore Med J2003445748

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CH Hui I Williams K Davis Clinical audit of the use of fresh-frozen plasma and platelets in a tertiary teaching hospital and the impact of a new transfusion request formInter Med J2005355283810.1111/j.1445-5994.2005.00803.x

17 

C Luk K M Eckert R M Barr I H Chin-Yee Prospective audit of the use of fresh-frozen plasma, based on Canadian Medical Association transfusion guidelinesCMAJ2002166153940

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B A Friedman H A Oberman A R Chadwick K I Kingon The maximum surgical blood order schedule and surgical blood use in the United StatesTransfus1976164380710.1046/j.1537-2995.1976.16476247063.x.

19 

T Chawla G N Kakepoto M A Khan An audit of blood cross-match ordering practices at the Aga Khan University Hospital: first step towards a Maximum Surgical Blood Ordering ScheduleJ Pak Med Assoc20015172514

20 

E A Abayomi G Zibwe J P Adewuyi A Mandisodza AZ Cakana Use of packed red cells in a major hospital in Harare, ZimbabweCent Afr J Med1999453546010.4314/cajm.v45i3.8453



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Article type

Original Article


Article page

12-14


Authors Details

N Thamarai Selvi, R Revathishree, Adayalam Chandana, Dost Mohamed Khan,


Article History

Received : 16-02-2021

Accepted : 26-02-2021


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