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- DOI 10.18231/j.achr.2021.067
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Xanthomatous meningioma, a rare histological variant: Case report
Introduction
Meningiomas are the most common primary intracranial tumor comprising approximately 33.8% of all Cranial Nervous System (CNS) tumors. [1] Currently, 15 different histological subtypes are known, and been categorized into WHO grade I, II and III. [2] Grade I constitute approximately 65-85% of all meningiomas. [3] Metaplastic meningioma is WHO grade I, which includes tumors containing different mesenchymal tissues i.e. osseous, cartilaginous, lipomatous, myxoid, or xanthomatous material. [4] Metaplasia is defined as “reversible transformation of one cell type into another different mature cell type”. Xanthomatous meningioma is a rare variant of metaplastic meningioma, which shows predominant xanthomatous tumor cells having central nucleus with vacuolated cytoplasm distributed in focal or diffuse pattern.
Case Report
A 43-year-old man presented with signs and symptoms of raised intracranial pressure. MRI brain was suggestive of 5.0 X 5.0 cm well circumscribed T1-hypo to isointense, T2-iso to hyperintense, heterogeneously contrast enhancing lesion with dural tail and attachment along the right sphenoid wing with mass effect. There was patchy T1 hyperintensity within the tumor. There were signs of raised intracranial pressure in the form of prominent perioptic CSF space, tortuosity of the optic nerve sheath and flattening of the optic nerve head ([Figure 1]A). There was tentorial thickening with tumor extension medially causing compression and distortion of the right cerebral peduncle and midbrain ([Figure 1]B). It was labeled as right sphenoid wing meningioma and underwent surgical excision.
|
Author |
Age (years) |
Sex |
Location |
IHC |
Radiological findings |
|
Chougule et al. (2015) [5] |
24 |
Female |
Supratentorial + infratentorial |
EMA(+) PAS(-) Ki-67(3.2%) |
Heterogeneously CE |
|
Ersoz et al. (2019) [6] |
32 |
Male |
supratentorial |
EMA(+), adipophilin(+), CD68(+), Ki-67(3%), CEA(-), S-100(-), GFAP(-) |
T1 isointense, T2 heterogenous, weakly CE, lobulated |
|
Germanò et al. (1996) [7] |
2 |
Female |
Infratentorial |
EMA(+), VIMENTIN (+), PAS(-), GFAP(-), S-100(-) |
Homogenously CE |
|
Ikota et al. (2008) [4] |
61 |
Female |
Supratentorial |
EMA(+), vimentin(+), histiocytic markers(+), Ki-67(2.2%) |
Weakly CE |
|
Tang et al. (2012) [8] |
22 |
Male |
Supratentorial |
EMA(+), vimentin(+), GFAP(–), Ki-67 (< 1%) |
NA |
|
Tang et al. (2012) [8] |
68 |
Male |
Supratentorial |
EMA(+), vimentin(+), GFAP(–), Ki-67 (< 1%) |
NA |
|
Ishida et al. (2013) [9] |
76 |
Male |
Supratentorial |
EMA(+), CD68(+), vimentin(+), lysozyme(+), adipophilin(+), Ki-67 (2.1%) |
NA |
|
Kepes JJ (1994) [10] |
24 |
Male |
Supratentorial |
Vimentin(+), HAM-56(+), CD68(+) |
NA |
|
Ijiri et al. (2000) [11] |
10 |
Male |
Supratentorial |
CD68(+), Sudan III(+), vimentin(+), Ki-67 (< 5%), GFAP(–), CAM 5.2(–) |
NA |
|
Liu et al. (2014) [12] |
55 |
Female |
Supratentorial |
EMA(+), CD68(+), S-100 (scattered +), Ki-67 (1.6%) |
NA |
|
Roncaroli et al. (2001) [13] |
58 |
Female |
Supratentorial |
EMA(+), vimentin(+), S-100(–), Ki-67 (< 5%) |
NA |
|
Roncaroli et al. (2001) [13] |
27 |
Female |
Infratentorial |
EMA(+), vimentin(+), S-100(–), Ki-67 (< 5%) |
NA |
|
Roncaroli et al. (2001) [13] |
59 |
Female |
Supratentorial |
EMA(+), vimentin(+), S-100(–), Ki-67 (< 5%) |
NA |
|
Roncaroli et al. (2001) [13] |
70 |
Female |
Supratentorial |
EMA(+), vimentin(+), S-100(–), Ki-67 (< 5%) |
NA |
|
Roncarol et al. (2001) [13] |
49 |
Female |
Supratentorial |
EMA(+), vimentin(+), S-100(–), Ki-67 (< 5%) |
Plaque like appearance |
|
Roncaroli et al. (2001) [13] |
12 |
Female |
Supatentorial |
EMA(+), vimentin(+), S-100(–), Ki-67 (< 5%) |
NA |
|
Wong et al. (2018) [2] |
83 |
Female |
Supratentorial |
EMA(+), PR(+), vimentin (+), S-100(+), CD68(+), CD11c(+), p53 (weak+), CK(–), CD34(–), Ki-67 (< 1%) |
Isointense, heterogeneously contrast enhancing |
|
Present case |
43 |
Male |
Supratentorial |
EMA(+), CD68(+) |
Well circumscribed T1-hypointense, T2-iso to hyperintense, heterogeneously contrast enhancing lesion with dural tail and attachment along the right sphenoid wing |
Neurohistological examination showed two different cell lineages admixed with each other. It revealed nodules of classical meningothelial cells with round to oval nuclei, and bland chromatin ([Figure 2]A-C). There are variable sized nodules of tumor cells with syncytial pattern of arrangement. Typical whirling pattern is also noted ([Figure 2] B). Intermixed among these nodules of tumor cells, second type of cells are noted. These are lipid filled foamy histiocytes or xanthomatous cells with interspersed needle shaped cholesterol cleft ([Figure 2]C). Xanthomatous cells show vacuolated cytoplasm with central nucleus. Occasional multinucleated giant cells were also present along with the histiocytes ([Figure 2]D). On immunohistochemistry analysis, meningothelial cells show strong Epithelial Membrane Antigen (EMA) positivity. Xanthomatous cells also show focal positive reactivity for EMA in the background. CD68 immunoreactivity is only shown by xanthomatous cells while meningothelial cells remain nonreactive ([Figure 2]E).
Discussion
In 1994, Kepes described the first case of Xanthomatous meningioma. [10] The tumor is reported in a wide range of age group from children to elderly patients and can be localized in supratentorial or infratentorial regions without any specific predilection (6) (Table 1). [2], [3], [4], [10], [9], [5], [6], [7], [11], [12], [13], [8]
On MRIs of the brain, these metasplatic meningiomas are usually iso- to hypointense on T1 and iso- to hyperintense on T2 weighted MRI. Katayama et al reported evidence of hyperintense lobules on both T1 and T2 weighted MRI images, and hypodensity on CT of the brain in xanthomatous meningiomas. These findings suggest high lipid content in the tumor. [1] Metaplastic meningiomas typically inculcate histopathological features of their transformed tumor subtype. [14] Xanthomatous changes may also occur as primary xanthomatosis in hypercholesterolemia or as secondary xanthomatosis in neoplasm or inflammatory conditions (Figure 2A, B). Xanthomatous meningiomas show focal or diffuse xanthomatous changes in them along with meningothelial tumor cells. Meningothelial and transitional variants often show fat accumulation whereas neoplastic cells in xanthomatous meningiomas are filled up with lipids appearing as foamy cell with cholesterol clefts (Figure 2C). [2] Macrophages surround these neoplastic transformed cells, hence it is essential to carefully establish the origin of these xanthomatous cells. Xanthomatous meningioma does not show inflammation and is different from xanthogranulomatous inflammatory changes. [4]
Immunohistochemistry may help in differentiating xanthomatous cells from macrophages. Xanthomatous cells resemble macrophages but show EMA staining, suggesting meningothelial origin. EMA negative cells are believed to be macrophages that have migrated due to tumor degeneration (Fig 2E,F). [6] High CD68 expression could also be a characteristic feature due to abundant intracytoplasmic lysosomes in these malignant cells (Fig 2G). [4] Furthermore, desmosomal and hemidesmosomal junctions, which create a “jigsaw puzzle” between adjacent neoplastic cells is highly suggestive of meningothelial origin of xanthomatous cells. [2], [15] In these tumors, xanthomatous areas stain negative for glial fibrillary acidic protein (GFAP) and stain positive for adipophilin, an antibody suggesting the presence of cytoplasmic lipid granules. [9]
Although exact pathophysiology behind these tumor is not known, Ishida et al. suggested metabolic abnormality in tumor cells resulting in xanthomatous changes. [9] Ijiri et al reported radiation associated xanthomatous meningioma in a 10-year-old-boy who received radiation for intracranial ependymoma at the age of 2 years. [11] Taraszewska et al reported rare xanthomatous phenomenon in atypical and anaplastic meningiomas. [15] Wong et al suggested that instead of actual histiocytic metaplasia, degenerative processes in tumors itself result in these xanthomatous changes. [2]
The differential diagnosis of xanthomatous meningioma include lipomatous meningioma, microcystic meningioma, and clear cell meningiomas. Lipomatous meningioma show mature adipocytes juxtaposed to neoplastic cells. Microcystic meningiomas can be differentiated by abundant cystic spaces formed by meningothelial cells. Clear cell meningioma show stromal and perivascular collagen unlike xanthomatous meningiomas. [2], [6]
Conclusion
Xanthomatous cells originate from meningothelial cells as shown by the immunohistochemical profile of the cells. It suggests true metaplasia of neoplastic cells into xanthomatous cells. Macrophage migration into tumor is due to the degenerative/inflammatory process within tumor cells, and its distinction from xanthomatous cells is crucial for the correct diagnosis and timely management.
Conflicts of Interest
The authors declare that there are no conflicts of interest regarding the publication of this paper.
Source of Funding
None.
References
- Y Katayama, T Tsubokawa, A Tanaka, M Koshinaga, N Nemoto. Magnetic resonance imaging of xanthomatous meningioma. Neuroradiology 1993. [Google Scholar]
- Y P Wong, G C Tan, R Kumar. Xanthomatous meningioma: A metaplastic or degenerative phenomenon? . Neuropathology 2018. [Google Scholar]
- L Rogers, I Barani, M Chamberlain, T J Kaley, M Mcdermott, J Raizer. Meningiomas: knowledge base, treatment outcomes, and uncertainties. A RANO review. J Neurosurg 2015. [Google Scholar]
- H Ikota, Y Nakazato. A case of metaplastic meningioma with extensive xanthomatous change. Neuropathology 2008. [Google Scholar]
- F Roncaroli, B W Scheithauer, R H Laeng, G Cenacchi, P Abell-Aleff, M Moschopulos. Lipomatous Meningioma: A Clinicopathologic Study of 18 Cases With Special Reference to the Issue of Metaplasia. Am J Surg Pathol 2001. [Google Scholar]
- M Ishida, T Fukami, N Nitta, M Iwai, K Yoshida, A Kagotani. Xanthomatous meningioma: a case report with review of the literature. Int J Clin Exp Pathol 2013. [Google Scholar]
- L Liu, J Stone, J T Hoffpauir, Z Xiong. Histiocytic meningioma: A distinctive subtype of meningioma?. Intractable Rare Dis Res 2014. [Google Scholar]
- H Tang, H Sun, H Chen, Y Gong, Y Mao, Q Xie. Clinicopathological analysis of metaplastic meningioma: report of 15 cases in Huashan Hospital. Chin J Cancer Res 2013. [Google Scholar]
- R Ijiri, Y Tanaka, M Hara, K Sekido. Radiation-associated xanthomatous meningioma in a child. Child’s Nervous Syst 2000. [Google Scholar]
- M Chougule, V Pawar, S Chivte, S Jagtap. Xanthomatous meningioma - a rare case report. Int J Health Sci Res 2015. [Google Scholar]
- S Ersoz, Sagnak Yilmaz, Z Eyuboglu, I Yazar, U. Xanthomatous meningioma: a case report. Turkish Neurosurg 2016. [Google Scholar] [Crossref]
- J J Kepes. Lipidized Meningothelial Tumor Cells in “Xanthomatous” Meningioma Express Macrophage Antigen. J Neuropathol Exp Neurol 1994. [Google Scholar]
- A Germanò, S Galatioto, G L Rosa, M Caffo, E Cardia. Xanthomatous posterior pyramid meningioma in a 2-year-old girl. Child’s Nervous System 1997. [Google Scholar]
- Y-H Choi, C-Y Choi, C-H Lee, H-W Koo, S-H Chang. Metaplastic Meningioma Overspreading the Cerebral Convexity. Brain Tumor Res Treat 2018. [Google Scholar] [Crossref]
- A Taraszewska, E Matyja, J Bogucki. Xanthomatous changes in atypical and anaplastic meningiomas. Light and electron microscopic investigations. Folia Neuropathol 2000. [Google Scholar]